{
  "certificate": {
    "id": "2020-014",
    "title": "CODECHECK certificate 2020-014",
    "url": "https://codecheck.org.uk/register/certs/2020-014/",
    "wikidata": "Q141269526"
  },
  "paper": {
    "title": "Patterned perturbation of inhibition can reveal the dynamical structure of neural processing\n",
    "authors": [
      {
        "name": "Sadra Sadeh",
        "orcid": "0000-0001-8159-5461"
      },
      {
        "name": "Claudia Clopath",
        "orcid": "0000-0003-4507-8648"
      }
    ],
    "reference": "https://doi.org/10.7554/eLife.52757",
    "abstract": {
      "text": "<jats:p>Perturbation of neuronal activity is key to understanding the brain’s functional properties, however, intervention studies typically perturb neurons in a nonspecific manner. Recent optogenetics techniques have enabled patterned perturbations, in which specific patterns of activity can be invoked in identified target neurons to reveal more specific cortical function. Here, we argue that patterned perturbation of neurons is in fact necessary to reveal the specific dynamics of inhibitory stabilization, emerging in cortical networks with strong excitatory and inhibitory functional subnetworks, as recently reported in mouse visual cortex. We propose a specific perturbative signature of these networks and investigate how this can be measured under different experimental conditions. Functionally, rapid spontaneous transitions between selective ensembles of neurons emerge in such networks, consistent with experimental results. Our study outlines the dynamical and functional properties of feature-specific inhibitory-stabilized networks, and suggests experimental protocols that can be used to detect them in the intact cortex.<\/jats:p>",
      "source": "CrossRef"
    },
    "openalex": "https://openalex.org/W3008505973",
    "wikidata": "Q89775486"
  },
  "codecheck": {
    "codecheckers": [
      {
        "name": "Iain Davies",
        "orcid": "0000-0002-5361-6285"
      }
    ],
    "check_time": "2020-07-28T10:00:00",
    "repository": "github::codecheckers/Sadeh-and-Clopath",
    "report": "https://doi.org/10.5281/zenodo.3967326",
    "type": "community",
    "venue": "codecheck",
    "summary": "Some of the original MATLAB code was provided on ModelDB. This code was successfully  rerun and reproduced some of the figures in the original paper. However this was a small subset of all the figures in the paper.\n",
    "manifest": [
      {
        "file": "codecheck/figures/GeneralActivity_SpecPert__1.png",
        "comment": "manuscript Figure 2A Bottom"
      },
      {
        "file": "codecheck/figures/SpecActivity_SpecPert__1.png",
        "comment": "manuscript Figure 2B Bottom"
      },
      {
        "file": "codecheck/figures/PertChange_SpecPert__1.png",
        "comment": "manuscript Figure 2C Bottom"
      },
      {
        "file": "codecheck/figures/SpikingActivity.png",
        "comment": "manuscript Figure 5A"
      },
      {
        "file": "codecheck/figures/SpikingNet_SpecActivity_SpecPert__inh.png",
        "comment": "manuscript Figure 5B Right"
      },
      {
        "file": "codecheck/figures/SpikingNet_PertChange_SpecPert.png",
        "comment": "manuscript Figure 5C"
      }
    ]
  }
}